Therapeutic role of vitamin B12 in patients with chronic tinnitus: A pilot study Therapeutic role of vitamin B12 in patients with chronic tinnitus

Abstract

Background: True tinnitus has no audible acoustic origin and is a phantom auditoria experience originating from a cause or trigger in the cochlea, brainstem, or at highly centers. The Jastreboff neurophysiologic hypothesis, which emphasizes that tinnitus is a subcortical sensation and originates from the interpretation of weak neuronal activities in the peripherals, is the most widely recognized.

Aim: This research seeks to understand the function of vitamin B12 in the management of chronic tinnitus.

Methods: A total of 100 individuals participated in this randomized, double-blinded pilot study, of whom 50 in Group A (patients) obtained intramuscular treatment of 1 ml Vitamin B12 (2500 mcg) once a week for a duration of six weeks, while the remaining 50 subjects in Group B (controls) obtained isotonic salines as a placebo. Pre- and post-treatment audiological and a Vitamin B12 testing were performed on the subjects.

Results: When standard dosages of vitamin B12 were set at 250 pg/ml, 43% of the overall tinnitus patients showed deficiencies. Upon receiving Vitamin B12 medication, individuals in Group A with Vitamin B12 insufficiency significantly improved their average tinnitus intensity index value and visual analogue scale (VAS), according to a paired t-test.

Conclusion: This study shows the substantial predominance of Vitamin B12 deficiency among >>> and the improved performance in tinnitus severity results and VAS in cobalamin-deficiency patients receiving intramuscular Vitamin B12 once a week for six weeks. It also establishes a connection between cobalamin deficiency and tinnitus, suggesting that B12 may be used therapeutically in cobalamins-deficient tinnitus subjects.