Evaluation of the Serum Levels of thyroid hormones in newly diagnosed patients with Chronic Lymphocytic Leukemia

Abstract

Background: Chronic lymphocytic leukemia (CLL) is the most prevalent form of adult leukemia in Western societies, constituting 25% of all adult leukemias and 25% of non-Hodgkin lymphomas. The current work designed to evaluate the serum levels of thyroid hormones as an indicator of prognosis for newly diagnosed chronic lymphocytic leukemia.

Patients and methods: This research employed a cross-sectional design and included fifty newly diagnosed patients.  All patients were chosen from outpatient clinic and inpatients of Internal Medicine department, Al-Azhar University Hospitals (Damietta). All submitted to systematic clinical evaluation. Then, thyroid hormones were measured and correlated with the disease severity.

Results: There was significant correlation between Free T3, spleen size, white blood cells, absolute lymphocytic count, platelet count, C-reactive protein, and albumin.  Although no substantial correlation was observed between free T3, age, hemoglobin and free-t4. Area under the curve was 0.57 for differentiation between mild and moderate conditions. Area under the curve was 0.81 for differentiate between mild and severe conditions (p=0.003).

Conclusion: Thyroid hormones in cases of CLL could be used as predictors of disease severity and prognosis.